Marketing Analysis of GOD Essay

Company Description: GOD is now a fast-growing furniture and furnishings company brand in Hong Kong. They describe them as â€Å"More Than Just a Furniture Store†. GOD is the phonetic sound of the Cantonese slang â€Å"to live better† which a basic human desire all around the world. The founder of GOD – Douglas Young and Benjamin Lau opened the first GOD store at Ap Lei Chau in 1996. Within 2 years, two more shops opened in Central and Tsim Sha Tsui respectively. In 2001, GOD has opened a 20,000 sq.ft. flagship store in Causeway Bay. The mission of GOD has always been â€Å"to define a new Hong Kong identity† – by exploring age-old oriental traditions and updating them with modern consumers in mind, their demonstrations of the techniques and wisdom of past generations in the east still has a place in the future world. Most of the furniture of GOD is made in China to their stringent standards of quality and workmanship. Their products range from furniture, bathware, kitchenware to even lighting and carpets. Among these various products, furniture occupies the highest proportion of sales revenues. What makes GOD different from other convectional furniture and furnishing company is that all of their furniture is designed by local designers. The company is strongly against today’s mass produced and soulless products. The main theme of their furniture is creative, comfortable, and multifunctional. In order to surprise their customers, GOD constantly turns out new items on a weekly basis. Because the marketing strategy in GOD is so clear that make the company become one of the few furniture companies that can still make a profit, and even expand their business, in the time of economy downturn in HK these years. Situation Analysis: 1. SWOT Analysis: Internally, GOD has a management team with designing knowledge which could perfectly apply to the daily management in the company. Small size of management team also benefits the company with the efficient division of  labor. Despite the fact of having numerous competitors with lower price, G.O.D. is still taking the leading role in the industry with its unique offerings of the oriental tradition Asian design in products, as well as the extraordinary decoration in each branch . G.OD is expanding its market share by connecting to other different industries, so as to attract more customers from different aspects. The diversification of production and also the â€Å"custom made† strategy contribute to the company as it prevent excess inventory. Moreover, its own R&D team takes a big responsibility in fulfilling the demand of the customers in having a better quality. Other than all those favorable circumstances, G.OD is still encountering certain weaknesses. Due to the short history of establishment, G.O.D. is lack of experience and specialization. Its relatively high price and narrow choice of products has also prevented the visit and purchase of customers. Also, due to the limited capital inflow in the company, GOD is still not able to develop a large R&D team; it also regards advertisement as a big burden for the company. Regardless of the success of the manufacturing approach, it, on the other hand, has lead to the high cost of production as it could not achieve the economy of scale. Favorable external factors include the increasing upscale market which people are more concerned about quality of life, there are only few and not well-established local competitors, and as the economic is recovering, there are more opportunities. Ergonomics is one of the most popular topics in furniture industry because the customer’s perceived value can be raised by introducing it. Unfavorable external factors include the taste of customers which people like international culture more, like Japan. In addition, the favorable investment condition attracts competitor from foreign countries. 2. Industry analysis: The furniture and furnishing industry has a long history in Hong Kong. It includes the production of household, office and furniture, as well as  bedding and parts of furniture. There are 249 furniture manufacturers in Hong Kong, employing more than 704 people as at Sep 2002. Around 90% of them are small companies engaging less than 10 people . Although it is not the major industry in the local market, the competition is very keen. In terms of market segmentation, the current furniture industry in Hong Kong is generally divided into three main categories: high-end, middle-end and lower-end market. However, in the past, the craft-based, labor-intensive furniture industry was one of the oldest industries in Hong Kong. It was developed to meet local demands. At that time, the furniture industry was dominated by a large number of small firms and could be divided into three major sectors, namely, wooden furniture, rattan furniture and metal furniture . After the economic crisis in 1998, many small companies went bankrupt and customers’ incentive on buying furniture was lower. To maintain their competitive power, many large companies strive to reduce their costs and increase their efficiency. Some relocate their manufacturing operations to other areas with lower operation costs like Mainland China. Foreign manufacturers are taking steps to strengthen their domestic production through production specialization. Hong Kong’s furniture makers also start to establish their own brands and some concept stores in order to develop their unique product lines to differentiate their firms from the others. Companies like GOD and Franc Franc are the most apparent examples which produce products with Hong Kong local characteristics and Japanese culture respectively. Recently, due to the economic recovery and the change of customer trend, people are going to be responsive to the new trends and design of furniture. Thus, the industry is going to produce products to cater the needs of Hong Kong people. Also, many furniture manufacturers become more careful about the choice of raw materials to meet international standards, such as compliance with legal or other environmental requirements in their target markets. Because of the limited living space in Hong Kong, the industry produces the furniture which is highly practical and multi- functional. Moreover, most of them embrace innovative designs and combinations of furnishings which allow them to save home spaces and provide a sense of style and modernism. To cater the growing trend and design of furniture which correspond to their taste and lifestyle, the industry produces DIY furniture which can let consumers to make their ‘unique’ furniture with their own styles. Moreover, most of them are made of the environmental friendly materials for production. 3. Competitor Analysis: Competitors in relevant market: There are three main competitors of GOD in Hong Kong, accordingly Franc Franc, IKEA and PRICERITE. Their target market segments do not necessarily the same but do have some overlapping as they both target on the market segments of middle-income level families. Further, the mission of their competitors also stress on developing a new concept of life style to Hong Kong people. Franc Franc’s company would invest over 30 million dollars in Hong Kong and expect there will be 36 million HK dollars gross profit in the first year. There will also be 2 or 3 new branches opened in the next few years. They will be mainly located in some big shopping malls. IKEA have 4 branches in Hong Kong mainly located near big housing town. IKEA is the most well known furniture company in Hong Kong due to the massive advertising programs. The concepts of their design are simple, multi-functional and sustainable. They also have a successful and well-developed customer service system which helps them to develop the loyalty of their customers. PRICERITE’s target group mainly focuses on lower income families. They  provide a relatively low price to their customers, thus helping them to develop a low cost, comfortable and multifunctional living environment. They have over 45 branches in Hong Kong so as consumers can easily find a PRICERITE nearby. Comparative advantages: 1. GOD—Uniqueness of local culture In these years, many industries especially those expose frequently to young people like filmdom and musical industry, advocate local original design and innovation. This atmosphere makes young people create a good feeling to Hong Kong local products. Today, GOD is the unique furniture store with strong â€Å"Hong Kong† concept. What Hong Kong concept here means is Hong Kong’s own culture and social atmosphere. GOD is a local brand and all of their exclusive designers are local. GOD claims their products have â€Å"soul† because their products can turn out local people’s opinion and attitude to lives. It can attract a group of Hong Kong new generation who like to show off their characters and tastes by their home furniture . 2. Franc Franc—Adhere to Japanese-styled goods The trend in Japan always is a benchmark for the young people in Hong Kong. It is because the young people in Hong Kong think Japanese always stand on the tips of the trend. Thus, most of them are adherent to Japanese-styled goods. Many Japanese brands like Fancl and Sanrio have successfully developed their business in Hong Kong. Their successes are also based on this reason. Franc Franc is the sole furniture concept store with Japanese style in Hong Kong. This make it exclusively enjoys the adherent from Hong Kong young people in this market . 3. IKEA—Cost Leadership To provide goods with high quality at relatively low prices, IKEA drives tough bargains with its suppliers in order to employ lowest cost suppliers  of raw and semi-finished goods from all over the world. IKEA Also, their products developers seek out manufacturers who can produce in the most cost-effective way and designers always work with solutions that result in a low price. This cost-focused supply chain model results in getting the goods with cheapest price and good quality.

Gourmet Products Inc. Essay

Gourmet Products Inc. (GPI) is a Canadian publicly traded retailer of aged balsamic vinegars, culinary sauces, spices, herbs, and seasonings. Products are sold globally through several Internet sites created and operated by GPI. On August 15, 20X0, GPI completed the acquisition of all the common shares of Abruzzi Oils Inc. (Abruzzi), an Italian producer and retailer of specialty olive oils, for cash consideration of C$6,000,000. The acquisition cost was allocated to the fair value of the identifiable assets and liabilities. The acquisition cost included a bottling machine with a book value of $400,000 and a fair market value of $750,000. However, to avoid any unnecessary reporting complications, the entire purchase discrepancy related to this machine was allocated to goodwill. GPI intends to keep the Abruzzi name and brand intact. Operations in Italy will be maintained, but GPI will import some of the olive oil production to Canada. The Abruzzi line of speciality olive oils will be featured on all of GPI’s Web sites. In preparation for ongoing operations, GPI has temporarily transferred two managers and five employees to Italy to work at the Abruzzi home office for a period of two years to ensure the transition runs smoothly and that the scale of operations can be increased to meet the forecasted sales growth. GPI is recording wages paid as consulting fees and is no longer taking source deductions. One manager has recognized that the move would cause undue stress on his family if they remained in Canada so he has decided to take his wife and children with him for the two-year period. GPI has just negotiated the purchase of a labelling machine in Italy for EUR 200,000. The equipment is expected to be useful for a period of 12 years. GPI has borrowed EUR 200,000 from the Banca Cammerata in Italy to finance  the equipment purchase. The loan, dated July 1, 20X0, is at 7% and is repayable in euros in 15 equal annual instalments, commencing August 1, 20X0. The interest is payable monthly in euros by GPI. The ownership of the labelling machine was transferred to Abruzzi on September 1, 20X0, in exchange for a EUR 200,000 note. The terms of the note are similar to the terms GPI negotiated with the Banca Cammerata, except that GPI is not charging Abruzzi any interest. The CFO of GPI stated this type of structure would minimize the foreign currency risk that GPI is exposed to. On the basis of an extensive review of the relationship between GPI and Abruzzi, Abruzzi has been classified as a foreign operation in accordance with IAS 21. In accordance with IFRS, Abruzzi revalued its land and building asset grouping to fair market value, resulting in an increase to the land and building account of EUR 20,000. Abruzzi’s accountant recorded the offsetting credit as a gain in profit and loss. A revaluation loss of EUR 5,000 had been recognized for land and buildings in the previous year. The corporate tax rate in Italy is considerably less than Canada’s combined provincial and federal rates. Both GPI and Abruzzi have a September 30 fiscal year end. GPI’s usual wholesale markup on its product imported is 60%; however, GPI has been acquiring goods from Abruzzi at 150% above Abruzzi’s cost. The decision to use 150% above Abruzzi’s cost was made by the CFO. As a result, GPI has had a very low profit margin on its retail sales of Abruzzi olive oils. You are Asif Majarani, a senior audit manager working in the assurance department of Majarani Associates, CGAs, a CGA firm in Winnipeg. Majarani Associates has three other specialized departments — advisory, taxation, and transaction services — with three other partners, one managing each  department. Your firm has been engaged to prepare the consolidated financial statements for the fiscal year ending September 30, 20X0, for GPI. This is the third year the firm has been engaged by GPI. You recently met with Ed Moore, CEO of GPI, on October 15 to obtain additional information. Moore mentioned that he had some concerns about the upcoming project of converting the existing payroll system to a new technology platform. A new payroll software system has been purchased since the payroll system currently in use is designed for a small company. GPI’s growth has strained the payroll system’s ability to provide timely payroll processing. Delays in payment of payroll have caused frustration for employees, although this does occur on an infrequent basis. The IT director is strongly suggesting that a direct cutover conversion approach be taken so that the new system can be used as soon as possible to realize the benefits. It is also the least expensive approach. Moore is concerned that this is a risky approach and he believes that a parallel conversion would be a better option. He is particularly concerned since he has heard that other companies have found errors during the implementation of this specific software system, although these errors are easily resolved once identified. Furthermore, since this is the first time GPI has been required to prepare consolidated financial statements for its shareholders, Moore is concerned about how the users will be able to differentiate between the financial positions and results of operations for the two separate entities. Required a) In your discussion group, analyze the case as a whole and identify all the issues to be included in the report to the CEO.  Note: Candidates must participate in the online discussion. Failure to post in the online discussion and respond to the posts of others will result in failing the discussion-based communication competencies. b) Prepare a report to the CEO (900 to 1,100 words), listing the adjustments that should be considered in preparing the consolidated statements. You should also address any other issues raised in the case. Complete this report independently of your group and submit it as a hand-in assignment.

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Corporate Finance - Assignment 03 Example | Topics and Well Written Essays - 1500 words

Corporate Finance - 03 - Assignment Example The study will be conducted for five days from 23rd December 2014 to 27th December 2014. The equipment is needed in January 2015. The estimated transportation cost is AED 5 million. The company intends to spend the remaining AED 50 million towards the equipment purchase. The equipment is quoted to cost  £ 860,000 and â‚ ¬ 1,090,000 in pounds and Euros respectively. The study of the currency movement will aid the purchase at a lower price. Therefore, this assignment presents a five-day exchange rate in a table format showing the value of AED 50 million, for each day, in both the currencies (Pounds and Euros). For each of the five days, the cost of the purchase and the impact of the decision are presented. Last, a report that provides justifications that the decision made is favourable to the company also is provided. For the purpose of purchasing the equipment, the currency used for the transaction is the Euros. The table 3 below shows the cost of the equipment in AED based on the exchange rates observations presented in table 1 above. The equipment is quoted to cost â‚ ¬ 1,090,000. Therefore, after incorporating the exchange rates, the costs are below. From the table 3 above, the company will spend (1,090,000/0.223548) = AED 4,875,910 to purchase the equipment on the first day. â‚ ¬1,090,000 is the price quoted in Euros. In order to determine the cost of purchasing the equipment on day 1, the quote price is divided by the exchange rate (AED/ £) on that day. Recapture that AED 50 million was allocated for the expenditure. Therefore, by making the decision to purchase the equipment, the company will save (50,000,000 – 4,875,910) = AED 45,124,090 for the reason that the equipment will be worth less than the planned cost (XE Live Exchange Rates, 2014). The company’s capital expenditure will be significantly reduced, thereby increasing its financial flexibility (ability to pursue other profitable investments). The

Did the sophists deserve their bad reputation Essay

Did the sophists deserve their bad reputation - Essay Example Plato himself seemed to hold them in low esteem. Aristotle denigrated them for their lack of interest in pure knowledge. Later, self-professed Sophists seemed to pervert the basic tenets of the movement for personal gain. Because these itinerate teachers made money off what many perceived as deception and devaluation, the Sophist's reputation has been viewed with distrust and scorn. Even today, their full contribution is not understood. The question is, "Did the Sophists deserve their bad reputation" The answer lies in the examination of several areas. First, the emergence of the Sophists threatened the status quo and the reigning aristocracy. Because the word itself means clever, people were instantly suspicious of someone who might be too tricky or too smart, especially the wealthy and ruling classes. Because they were teachers that received fees for their educational services, the traditional Greeks were afraid that the lessons taught might conflict with their definition of virtuous and necessary education. They did, in a way. The idea of teaching virtue, for money, incensed the people of the time. They felt that the education of young men to be of wise judgment and upstanding character should be left to the church, not to traveling teachers who expected to be paid! Already the occupations of these mysterious travelers cause suspicion and anger among the people who had become very stable in their beliefs. Another area of teaching that ... Yet, the Sophists also claimed to be great rhetoricians with a flair for disagreeing with current thought and encouraging cynicism in others. While the rhetoric of the senators had always been in supporting what is right and virtuous for individuals and societies, the Sophists were implying that rhetoric could be employed for any purpose, even those that were antithetical to common belief.. People were highly disturbed to realize that someone could use rhetoric to convince them of something untrue. After all, the Sophists were gaining a following of young men who were drawn to their ideas. Basically, the Sophists forced the question "What is right" into the wide open public sphere. Instead of just accepting that right and virtue are always obvious and will always prevail, people could not avoid the new interpretations offered by the Sophists. Those that stood the most to lose, the wealthy and powerful, cried out against the heresy, but those that had little to lose could afford to listen with interest. The revolutionary new teachings spanned education, religion, politics and ethics, challenging the established beliefs held for centuries. This belief purported that people act in certain ways because that is how they ought to act. This prescribed action was based upon the will of the god or gods, or upon some other moral order. People generally believed that these moral tenets were a fixed and unchanging part of nature itself. The Sophists interjected that morals and ethics were not fixed by nature at all but were a dynamic part of society; codes of behaviors changed by the views of society. This conventionality meant that some people, some societies, might believe

Project Management Essay Example | Topics and Well Written Essays - 500 words

Project Management - Essay Example The project is to launch a new product, a multiple container system that requires minimal cabinet storage space in the consumer’s home, within nine months from now. The product is more described in greater detail as similar to a competitor's product but will have significantly more features. As reported, this product will open new markets for the sales channel, lay the foundation for add-on products, and generate new revenue. The objective therefore is for sales and marketing personnel to make the necessary preparations in terms of designing appropriate marketing strategies encompassing the 4Ps: product, pricing, place and promotions to be used for the launching of the new product. This research aims to evaluate and present such deliverables: 1. Sales Team 1.1 Generate sales forecasts 1.2 Set price for the new product 1.3 Familiarize the team with potential add-on products 1.4 Identify potential customers within sales boundaries 1.5 Conduct sales force education and orientation for the new product 1.6 Synchronize time schedule of designing strategies with manufacturing and marketing team 2. Marketing Team 2.1 Design advertisements and promotional campaign for the new product 2.2 Identify strategic markets 2.3 Monitor prospective competitors’ response to the new product 2.4 Provide all crucial marketing materials (brochures, product specifications and features, packaging) 2.5 Determine schedules for home sales events to launch the new product 2.6 Synchronize time schedule of identified activities with manufacturing and sales team.

Marketing on Women Essay Example | Topics and Well Written Essays - 500 words

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Design Proposal Assignment Example | Topics and Well Written Essays - 1000 words

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Seeds milk rather than cow's milk Literature review

Seeds milk rather than cow's milk - Literature review Example These peptides are in the form of epidermal and nerve growth factors and other growth inhibitors like MAF and MDGI. White blood cells exist in cow’s milk that is being sold to people. There are about 1.5 million white blood cells commonly observed in per millilitre of cow’s milk. Recombinant Bovine Growth Hormone is used in order to enhance rate of milk production. This hormone is directly injected into cows. It is a genetically engineered hormone and has direct linkage with prostate, breast and colon cancer. At a national average, every glass of milk consists of pus and it accounts for 322 million cell count. It is not safe for humans to intake such high level of pus (Buttriss, 2008). This ultimately leads to Crohn’s disease. Infected udders generate this form of pus and it is known as mastitis. Antibiotics are an essential component found in blood and milk of cows. There are wide array of diseases that affect cows and hence they are treated with the help of ant ibiotics. Antibiotic medicines are constantly injected in cows. Chemically laden ointments are also used so as to protect cows from chronic diseases. Four most common antibiotic drugs are noticed in dairy cows. Sulfa drugs contaminate about 38% of cow’s milk, specifically in United States. There is a negative correlation observed within milk intake and bone mineral density. Interleukin 6 found in cow’s milk results into cardiovascular disease. This shall influence osteoporosis and bone loss. Higher degree of non-fermented milk consumption eventually leads to high blood pressure, high insulin resistance and lower high density level of lipoprotein cholesterol. The negative impact of cow’s milk is observed in the form of reduced ability of children to absorb iron. Subtle blood loss is also common in infants consuming cow’s milk. Coronary Heart Disease is another adverse impact caused by milk consumption. Cancer risk is prominent with consumption of cowâ€⠄¢s milk. IGF-1 is present within

Innovation and Sustainability Essay Example | Topics and Well Written Essays - 500 words - 4

Innovation and Sustainability - Essay Example Therefore, this paper will explore two consumption and two production habits of humans that are related to the material resources. In addition, it will give recommendations on sustainable ways of producing and consuming these resources for the purpose of the present and future generation. Population growth continuously affects consumption of materials and environmental resources. With exponential growth, population density increases in a region. The number of population per 1000 population highly determines the amount of consumption of goods that come from the environment. Agricultural production of goods has to be increased with any increase in birth rates in a population. Going by the current trend, every household and in some cases every individual who can attain a driving license has a car especially in the US, which means more fuel consumption, hence, more exploitation of crude oil (Segger, 2011). Technology has contributed a lot to consumption of most goods. It is with technology that humans are able to consume coal out of a coal mine. Fuels that produce green house gases come as a result of the power of machines in exploitation and cutting down of trees which are a great source of carbon sink. All this is done just to satisfy human needs of consumption. For example, trees are cut down for building purposes and for fuel, while exploitation of fuels like petrol and diesel from crude oil is mainly for the current increase of vehicles on the road (Segger, 2011). Advancement of industrial revolution has immensely encouraged high production rate of consumer goods. With advanced technology, more agricultural goods can be produced due to the presence of technologies that can be used like those used to manufacture chemical fertilizers for the unfertile soils. Thus, more agricultural goods are being produced currently, despite the health impacts that some of the production methods like GMO have on human health (Segger,

Eating Healthily with a Busy Lifestyle Essay Example for Free

Eating Healthily with a Busy Lifestyle Essay Healthy eating is an essential part of a healthy lifestyle, yet it is often overlooked. As a wellness professional, it’s important to take care of your own wellness in order to maintain the right physical and mental state to help others. When hungry and busy, it’s easy to grab whatever’s closest or whatever sounds tasty at the moment. Unfortunately, the food that sounds best doesn’t always make us feel the best, and the most convenient foods are not often the healthiest. At the same time, healthy eating as a busy wellness professional does not have to become a chore. Many people end up with a misconception that healthy eating is more difficult than it actually is. It simply requires a little bit of planning and thought. The benefits of healthy eating far outweigh any extra time it requires. Written by Larry Lewis I and many others are promoting the benefits of living a healthy lifestyle, but what does that actually mean? In general, most would agree that a healthy person doesn’t smoke, is at a healthy weight, eats a balanced healthy diet, thinks positively, feels relaxed, exercises regularly, has good relationships, and benefits from a good life balance. Maybe I should start by trying to look at a few definitions for the word – lifestyle. A definition in The American Heritage Dictionary of the English Language says : ‘A way of life or style of living that reflects the attitudes and values of a person or group’. In an Encyclopedia of Public Health: Lifestyle is defined as: In public health, â€Å"lifestyle† generally means a pattern of individual practices and personal behavioural choices that are related to elevated or reduced health risk’. The World Health Organisation in 1946 defined health as ‘A complete state of mental, physical and social well-being not merely the absence of disease’. Wikipedia: defines a lifestyle as the way a person lives. This includes patterns of social relations, consumption, entertainment, and dress. A lifestyle typically also reflects an individual’s attitudes, values or worldview. A healthy lifestyle is generally characterized as a â€Å"balanced life† in which one makes â€Å"wise choices†. A final definition of lifestyle is: The aggregation of decisions by individuals which affect their health, and over which they more or less have control. What is the definition of Healthy Living? The World Health Organization (WHO), defines Health as a state of complete physical, mental, and social well-being, not simply just the absence of disease. The actual definition of Healthy Living is the steps, actions and strategies one puts in place to achieve optimum health. Healthy Living is about taking responsibility for your decisions and making smart health choices for today and for the future. So healthy living would consist of: Physical (For The Body) * Good Nutrition, Eating Right * Getting Physically Fit, Beneficial Exercise * Adequate Rest * Proper Stress Management Emotional Wellness (For The Mind) * Self-Supportive Attitudes * Positive Thoughts and Viewpoints * Positive Self-Image You Also Need to Give and Receive * Forgiveness * Love and Compassion * You Need to Laugh and Experience Happiness. * You Need Joyful Relationships With Yourself and Others. Spiritual Wellness * Inner Calmness * Openness to Your Creativity * Trust in Your Inner Knowing And all aspects of one’s self, must work in harmony to achieve wellness, so you need to create a balanced life. Why is it Important? Ahealthy lifestyle is a valuable resource for reducing the incidence and impact of health problems, for recovery, for coping with life stressors, and for improving quality of life. There is a growing body of scientific evidence that shows our lifestyles play a huge part in how healthy we are. From what we eat and drink, to how much exercise we take, and whether we smoke or take drugs, all will affect our health, not only in terms of life expectancy, but how long we can expect to live without experiencing chronic disease. Conditions such as heart disease, cancer, diabetes, joint disease, and mental illness are responsible for a vast number of deaths and disabilities. Currently, we rely almost exclusively on the provision of clinical care by highly trained health professionals as our major strategy to deal with these conditions. Many health problems can be prevented or at least their occurrence postponed by having a healthy lifestyle. * Why don’t you have a healthy lifestyle? It’s a busy life for most of us. And keeping ourselves healthy is all too rarely near the top of our list of ‘things to do’. Convenience often wins – we are all so busy that convenience is at a premium. Good Health Is ’Simple – But It’s Not Easy’ It is so important to make ‘keeping healthy’ a part of our day-to-day living habits. Your health depends on what you do throughout the day, everyday. A healthy lifestyle is absolutely vital. Here is a real simple solution – slowly improve your lifestyle in a step-by-step way. If you take one new health step every two months, for example, in two to three years you will be among the healthiest ten percent of people in the Western world. And boy will you see and feel the benefits. Improvements do not have to be large steps; take one small step for your health today, keep that one going, and add another one every two months. Have a plan – maybe introduce 6 improvements over the course of a year. Can You Adopt A Healthy Lifestyle? Whatever your age, fitness level or body shape, its never too soon or too late to start thinking about living healthily. You can take a step towards healthy living by making one change now to your daily life. That won’t be so hard will it? Are You Living A Healthy Lifestyle? Do you wake up with enthusiasm for the day ahead? Do you have the high energy you need to do what you want? Do you laugh easily and often, especially at yourself? Do you confidently find solutions for the challenges in your life? Do you feel valued and appreciated? Do you appreciate others and let them know it? Do you have a circle of warm, caring friends? Do the choices you make every day get you what you want? The Components Of A Healthy Lifestyle Eating Healthily The right nutrition is necessary to live a healthy lifestyle. Your body requires a well balanced dietevery day in order to maintain the adequate amounts of vitamins, nutrients and minerals needed to maintain a healthy body. To eat is a necessity, but to eat intelligently is an art. La Rochefoucauld French Writer An Active Lifestyle You will need to include fitness as part of your life. Physical fitness keeps your weight in check, helps you sleep better at night, prevents heart attacks and strokes and other health problems, and generally prolongs your life. Basically there are so many benefits of exercising that you really can’t live a full life without it. Those who think they have not time for bodily exercise will sooner or later have to find time for illness. Edward Stanley Earl of Derby Stress Management Emotional stress plays an important role in many illnesses, both directly and indirectly. People are also more likely to smoke, overeat, drink too much, work too hard, argue with others and so on, when they are feeling stressed. Thus, stress management is an important part of your new lifestyle, and meditation and relaxation techniques are truly a key part of living a healthy lifestyle. Diseases of the soul are more dangerous and more numerous than those of the body. Marcus Tullius Cicero Roman Philosopher Make Friends With Yourself Loving yourself is a key to a healthy, happy lifestyle. Self-esteem is all about how much people value themselves; the pride they feel in themselves, and how worthwhile they feel. Self-esteem is important because feeling good about yourself can affect how you act. The power of love to change bodies is legendary, built into folklore, common sense, and everyday experience. Love moves the flesh, it pushes matter around†¦ Throughout history, â€Å"tender loving care† has uniformly been recognized as a valuable element in healing. Larry Dossey Physician Powering Up Your Mind And Body Programme your mind for total success. Develop a vision, a compelling future that excites and inspires you, and focus on it daily. Don’t let anything knock you of course, or make you question its possibility. I promise you, by taking control of your thoughts, you will improve your life in a big way. In minds crammed with thoughts, organs clogged with toxins, and bodies stiffened with neglect, there is just no space for anything else. Alison Rose Levy Journalist Life Balance If you want to achieve a healthy lifestyle you must take steps to ensure you maintain a certain level of balance†¦ spiritually, physically, emotionally, socially, mentally and financially. You need to balance work and family, and all the other areas of your life without spreading yourself too thin and having a guilt trip when you do one thing, but think you should be doing another. All of the key areas of our lives overlap and interlink, effecting each other. Unless we create for ourselves satisfaction in each and every part of our life, we can never truly be fulfilled, or live a contented, happy and healthy life. No success in public life can compensate for failure in the home. Benjamin Disraeli British Prime Minister Being Healthy is so important. Just change one thing in your life today. Have a healthy lifebeginning now. Living a healthy lifestyle will bring you happiness, health and the life of your dreams. You can fit into your favourite pair of jeans again. You can enjoy all the benefits that perfect health offers you. You can feel your best at all times of the day. I have spent over ten years working in the area of personal development and in helping others to achieve their potential. It is the belief that everyone should be helped and encouraged to reach their full potential that motivates me in my work as a coach and blogger. I’m passionate about this because I have seen its effects in my own life and the lives of others. I am 100% committed to making the difference, and I pray this is obvious to you through my blog. Life Coaching with Larry I hope this article has helped you in some way today. If you have ended up asking yourself more questions instead of getting questions answered then maybe I can help you. Take up my free 30 minute session to see if life coaching is for you. Does this sound familiar? * In midlife transition and lost the spark and direction? * Looking for more clarity, meaning and joy? * Feeling stuck or confused about your future? * Want to do more, be more, achieve more? https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/ https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/ https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy- https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/ https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/ https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/ https://www.healthylifestylesliving.com/health/healthy-lifestyle/what-is-a-healthy-lifestyle/

Zara Organizational Structure

Zara Organizational Structure Structure relates to a skeletal framework of activities and processes in an organisation and specifies the roles of these in achieving goals and objectives of the organisation. According to (Mullins, 2009), a good structure is highly important due to the fact that decisions on structure are primary strategic decisions which can make or break an organisation. One important aspect of a good structure is the human element. Organisation structure should be designed so as to encourage employees and increase the morale and job satisfaction of organisation members which will result to overall organisation efficiency. (Mullins, 2006) describes nine basic considerations in the design of organisation structure. The fundamental step is to define organisational objectives to enable further analysis and comparisons of other forms of structure. Clarification of objectives A clear definition of objectives is vital to provide a framework for the design of structure of an organisation. Organisation objectives provide fundamental schemes for division of labour and creation of group units and sub units. Clearly stated aims and objectives will assist in decisions on the strategy and structural dimension to employ to achieve organisational objectives. Task and element functions Certain functions must be performed in order to produce a good or service, from the development of the good or service to finance of resources used in the complete processing. These functions are referred to as the task functions. The results of the task functions must be coordinated to ensure the efficient achievement of total objectives of the organisation. Element functions refer to vital parts of the management process and are supportive of the task functions such as human resources and public relations. Division of work An organisation needs to accomplish an overall task of allocating many different activities to groups of people or individuals to achieve its objectives. The division of work and grouping together of individuals should be organised according to a basic criterion to establish a coherent link between the activities involved. The division of work and linkage of activities occur in various ways such as specialisation, use of similar resources or common expertise of organisation members as the most commonly used basis for grouping activities. Others include division by product or service, division by location, division by nature of the work performed, division according to common time scales such as shift working, division according to staff employed such as allocation of work based on experience and so on. Centralisation and decentralisation The extent of centralisation or decentralisation refers to the point of critical decision making in an organisation which reflects patterns of authority in a structure. In centralised structures decision making authority is within the power of top management while decentralised structures, decision making authority is delegated (Rollinson, 2005). The arguments in favour of centralisation in an organisation entail the easier implementation of a common policy, easier coordination and management control, preventing sub-units from becoming too independent, over-head cost reduction and faster decision making because of the smaller number of people involved. In contrary, arguments for decentralisation include decisions being made at a point closer to operational levels, increased responsiveness to local circumstances, improved level of personal customer service, more flexible structure, control is distributed more evenly which provides opportunity for development for those lower down, and encouraging effect on motivation and morale of staff. Basically, decentralisation tends to be easier to implement in the private sector organisations than public sector ones where procedures and protocols are the order of the day. Decentralisation being a more flexible approach provides support for employee participation and empowerment at all levels which increases innovation and improves technology while centralisation ensures professionalism in all activities by maintaining effective coordination and overall control of the organisations activities as a whole. A mix of both such as being global and local, practically being decentralised with a central control and authority should produce an organisational advantage. A vivid illustration of decentralisation is the Zara fashion enterprise (cited in Mullins, 2009, p.596), where the company derived its success from integration of design, production, logistics and sales within companies globally rather than separating and outsourcing this different business elements unlike its contemporaries in the fashion industry, while still keeping control of all major operations in Spain. The company rejected rigid organisational structures in favour of a more flexible approach which comes from a highly integrated, fast and efficient form of communication between its global network of outlets and central hub of operations in Spain. The industry average time for introducing a design into the shops is six to nine months; Zara achieves this task in three to four weeks. What is peculiar here is that Zara only makes what is selling at the moment, store assistants and managers constantly get information about what is selling and how quickly it leaves the racks implyin g that local managers have a strong influence on their stores success and thus the company overall. On the other hand, an illustration of centralisation is that of Nissan Motor Company (cited in Certo and Certo, 2006, p.123), a successful global automobile manufacturing company where the new CEO ordered calls for the elimination of 30 per cent of production capacity in Japan due to recent financial difficulties. The CEOs plan is to help reduce expenses as well as close offices in New York and Washington with a view to centralise company operations in Japan to enhance success. Principles of organisation The ten principles of organisation include principles of the objective, specialisation, co-ordination, authority, responsibility, definition, correspondence, span of control, balance and principle of continuity. Span of control This refers to number of subordinates who report directly to a particular manager or supervisor. Span of control is larger at lower levels of the organisation where responsibility is concerned more with the performance of specific tasks. If span of control is too wide, supervising too many subordinates effectively becomes difficult and stressful for managers as well as planning and development, training and control. Narrow span of control may lead to low morale and initiative of subordinates due to close supervision level, and also increase administrative costs. Chain of command This refers to the number of different levels in the structure of the organisation, the chain of hierarchical command. Every employee must know there position within the organisation structure. The combination of chain of command and span of control determines the overall pyramid shape of the organisation and whether the hierarchical structure is flat or tall. Flat hierarchical structure depict a broader span of control and few levels of authority while tall structure depicts narrower spans of control and more levels of authority. There is no ideal hierarchical structure but it is best to have a balance of both. An illustration is Mc Donalds fast-food restaurants (cited in Certo and Certo, 2006, p.236). Mc Donalds decided to reorganise its global senior management team as a reaction to its recent poor financial performance. This involved creating two geographic areas of responsibility. The new positions focuses on managing operations in the Americas while the other in Europe, Asia and the Pacific. The new structure evolved with a view to create clearer lines of responsibility and more focus on the companys financial performance within the territories. The new organisation hierarchy was also aimed at helping the company make business decisions more quickly. Formal organisational relationships This refers to individual authority relationships arising from defined patterns of responsibility in an organisation. This are identified as; line relationships where there is a direct relationship between subordinate and supervisor; functional relationships between people in advisory positions, and line managers and their supervisors; staff relationships are usually personal assistants who exercise only representative authority. Line and staff organisation This provides a means of making full use of specialists while maintaining the concept of line authority. Project team and matrix organisation A project team refers to a separate unit set up temporarily for a particular project which is disbanded when the duration elapses while matrix organisation involves functional departments specialising in numerous activities. In conclusion, the overall effectiveness of the organisation will be influenced both by a healthy structural design, and by the behaviour of people who work within the structure. There are numerous variables and factors which influence the soundest structure. Nothing like a perfect organisation exists but it is crucial to establish a framework of order and system through which organisation activities can be planned, organised, directed and controlled. Since structure divides up the organisation into different parts and specifies what roles these will play in achieving specific aims and objectives, it also provides for control and coordination of the parts to achieve this goals. Basically, the essence of structure is the division of work among organisation members, the coordination of activities and various jobs which are inter-related. References Certo S.C and Certo S.T. (2006) Modern Management. 10th edn. Prentice Hall Mullins, L.J. (2009) Management and Organisational Behaviour. 8th edn. Financial Time Press Rollinson, D. (2005) Organisational Behaviour and Analysis: An Integrated Approach. 3rd edn. Financial Times/ Prentice Hall

Research into Cancer Stem Cells

Research into Cancer Stem Cells Cancers are composed of a heterogeneous mix of cells with varying differentiation, proliferation and tumourigenic properties. In vivo studies have demonstrated that within a cancer population, only percentage of cells are able to initiate tumour development [1]. It is widely believed that the heterogeneous groups of cells include a small population of cancer cells with stem cell properties: the cancer stem cell (CSC). These cells have the capacity to self-renew and differentiate asymmetrically and give rise to bulk populations of nontumourigenic cancer cells. Current cancer treatments may eradicate the tumour bulk but spare the populations of stem cells which are able to restore tumour tissue causing recurrence of the cancer. This may explain why initial tumour regression does not necessarily translate to improved patient survival in many clinical trials. Identification and characterisation of these stem cells may offer means of targeting cancer at its root. Cancer Stem Cell Definition The AACr workshop in 2006 defined a cancer stem cell as: A cell within a tumour that possesses the capacity to self-renew and to cause the heterogeneous lineages of cancer cells that comprise the tumour. Cancer stem cells can thus only be defined experimentally by their ability to recapitulate the generation of a continuously growing tumour.[2] Therefore the stem cell definition requires that cell possess 2 fundamental properties. Self renewal, the process whereby at least one daughter cell of a dividing stem cell retains stem cell properties Potency, the ability of cells to differentiate into diverse cells that comprise the tumour. [3]. It was agreed that defined CSCs may not necessarily derive from normal tissue stem cells, indeed one important and unanswered question is whether tumours derive from organ stem cells that retain self renewal properties or whether tumour stem cells are proliferative progenitors that acquire self-renewal capacity [2]. Normal Tissue Heterogeneity The continuous replacement of differentiated, functional cells by proliferation of more primitive cells in human tissue is a normal homeostatic process. Organs are composed of collections of differentiated cells that perform discrete functions [4]. The total cell population is regarded as constituting a cell division hierarchy [5]. The stem cell is central in the renewal hierarchy and has two functions within this model. It can act as the initiating cell in a cell division and differentiation process, producing a large family of differentiated descendants, a process known clonal expansion. Another function is for the cells to undergo division to produce two stem cell daughters identical to the initial stem cell and to replace the stem cells used in clonal expansion. This process is called self-renewal [6] and is shown diagrammatically in Figure 1. As cells move down the hierarchy they acquire the differentiated features associated with tissue function and the proportion of differenti ated cells increases. In this way the stem cell has the ability to maintain organ life [4]. This concept predicts the existence of three categories of cell within the population: Proliferating, self renewing stem cells; Proliferating non-renewing transitional cells (transit amplifying); Non-proliferating, differentiated end cells. Following division the stem cell can give rise to a transit amplifying cell that will undergo further rapid proliferation to produce offspring which expand the populations of cells arising from the initial division and progressively commit irreversibly to differentiation along one or several lineages[4]. An important feature of a stem cell is their ability to undergo asymmetric cell division giving rise to a progenitor cell and to a new stem cell. Somatic SCs reside in confined tissue compartments referred to as the niche. Here the microenvironment suppresses SC proliferation, resulting in a quiescent SC population. This population maybe triggered to proli ferate and differentiate in response to injury (Ghotra, 2009). Seven common and distinguishing features of stem cells have been described [4]: Stem cells comprise a small subpopulation of a given tissue. Stem cells are ultra-structurally unspecialized, with a large nuclear-to-cytoplasmic ratio and few organelles Stem cells can be pluripotent Stem cells are slow cycling but may be induced to proliferate more rapidly in response to certain stimuli Stem cells have a proliferatve reserve that exceeds an individuals lifetime An intermendiate group of transit amplifying cells exists The microenvironment plays a critical role in the homeostasis of the stem cell and the differentiation of its progeny. The stem cell is capable of division and clonal expansion. As cells differentiate they lose their proliferative potential. The stem cell can self renewal or divide to produce proliferative transitional cells. Tumour Heterogeneity It has been recognised for many years that tumours exhibit morphologic heterogeneity but they are also functionally heterogeneous in terms of cell proliferation and tumour forming capacity based on transplantation assays [7]. Heterogeneity within tumours is seen within individual tumours in terms of morphology, cell surface markers, cell proliferation kinetics and response to therapy. In vitro and in vivo observations suggest that most cancer cells do not proliferate and that loss of capacity to divide is a feature of the tumour. Only a small proportion of cells have the ability to form tumours in vivo, referred to as tumourgenicity. The cancer stem cell theory posits that neoplasms, like physiological tissue can be hierarchically organised, and that CSCs at the apex of this of this cellular hierarchy and seem to comprise of only a subpopulation of tumour cells are essential for its initiation [8, 9]. Two models have been proposed to explain tumours heterogeneity Stochastic and Hiera rchy, summarised in Figure 2. Both models account for the existence of a cell with stem cell properties, but only the hierarchy model predicts the existence of a stem cell at the top of a hierarchy, which the potential to produce all other cell types within the tumour. Stochastic Model The stochastic model predicts that a tumour is biologically homogeneous and the behaviour of the cancer cells is influenced by intrinsic (eg signalling pathways, levels of transcription factors) or extrinsic factors (eg host factors, immune response, and microenvironment). It is suggested that the randomness and unpredictability of these factors result in heterogeneity in many aspects of marker expression and tumours initiation capacity [10]. A key requirement of the stochastic model is that all cells are equally sensitive to such influences and that the cells can revert from one state to another. For this model to be functional all tumour cells are not permanently affected and all have equal capacity to be induced to one state or another and the changes upon the cell are not permanent [11]. A growth fraction of Hierarchy Model The second model is the hierarchy model which predicts that the tumour is a caricature of normal tissue development and a hierarchy where the stem cell is at the tops is maintained (Pierce) [7]. The cancer stem cell maintains itself and its clones by self-renewal. The cells also mature to produce differentiated offspring which form the bulk of the tumour and lack stem cell properties. As in normal tissue only a small percentage of the tumour population maintain the capacity for long term proliferation while most cells proceed forward down the differentiation pathway resulting in aberrant terminal differentiation [4]. Due to differences in characteristics, stem cells can be selected and enriched for. Variations in tumour growth rates may be due the effects of normal homeostatic mechanisms that regulate stem cells and transit amplifying cell reproduction or alterations of the stem cell niche microenvironment [4]. Much of the evidence for this comes from clonogenic and tumourgenic assay s, which will be discussed further. Hierarchy model contains cells that are composed of biologically distinct cells including cancer stem cells which are all have different functional properties. The stochastic model predicts that all cells are equal the cell heterogeneity is due to intrinsic and extrinsic influences upon the cells which result in heterogeneity of cell function. Experimental Evidence Early Work The first evidence for the existence of cancer stem cells came from functional cell proliferation studies in the1940s 1960s. Radiolabelling cells and autoradiography enabled measurements into the proliferation, lifespan and hierarchical relationships in normal and neoplastic tissues [10, 12]. From these studies came the proposal that tumours are caricatures of normal development including the existence of stem cells [7]. Much early work was on the cancer of the haematopoietic system. In the 1970s Clarkson and other groups carried out pioneering studies that established cancers exhibited functional heterogeneity [10, 13]. These include cytokinetic studies carried out in cell lines, murine models of the acute leukaemias and in vivo examination of leukaemia blast proliferation kinetics in human AML and ALL patients. The data showed that the majority of leukemic blasts were post mitotic and needed to be continuously replenished from a relatively small proliferative fraction. Only a smal l number of leukemic blast cells were cycling in vivo and of these two proliferative fractions were observed: a larger, fast cycling subset with a 24 hour cell cycle time and a smaller, slow cycling, with a dormancy of weeks to months. From this data it was suggested that the slow cycling fraction was generating the fast cycling fraction thought to be the leukemic stem cell population because they had similar kinetic properties to those observed for normal haematopoietic stem cells. This was a clear suggestion that tumours exhibit functional heterogeneity in terms of proliferative potential. Following the identification of these slow cycling cells it was predicted the inability to kill the leukaemic stem cells (LSCs) was the cause of relapse and failure of chemotherapeutic therapies. Whilst combining treatment with in vivo cytokinetic studies, investigators observed that LSCs respond to the depletion of the of the leukemic cell mass by go into cycle after chemotherapy. It was sugges ted the way to eliminate dormant LSCs was to find the window when they are cycling. Identifying and assaying the potential LSCs was a major stumbling block and characterising them was impossible. This was when attention focused on the clonogenic assay was adapted by several groups to assay AML which identified phenotype of AML cultures in vitro with differing proliferative potential, providing the further proof for hierarchy in AML [14-16]. Clonogenicity Definition of a clone A clone is an operationally defined as a group of cells derived from a single ancestor cell. Clonogenicity is the ability of a given cell population, when plated as single cells, to produce one or more clones. This can be measured by the clonogenic assay which can quantify the proportion of colony forming cells, as a percentage of plated population, referred to as colony forming efficiency (CFE). It has been suggested that colony-forming cells possess two fundamental properties of progenitor cells: the ability to give rise to differentiated descendents and the capacity for self-perpetuation [17]. Therefore the ability to measure the capacity of cells to form clones is a useful tool in the study of the cancer stem cell concept. Quantitative measurement of clonogenicity Development of the clonogenic assay. Puck and Marcus The first clonogenic assay In 1956 Puck and Marcus published a paper describing a cell culture technique for assessment of colony forming ability of single mammalian cells [18]. Plated in culture dishes with a suitable medium human cervical carcinoma cells (HeLa) were supplemented with a large number of irradiated feeder cells and the number of colonies formed was counted. Their technique was a simple rapid method for growing single mammalian cells into macroscopic colonies with a colony forming efficiency of 80 100% . The authors developed this assay further to enable quantification of the effects of high energy radiation on cell populations in vitro [18-20]. They plated HeLa cells and measured their response to x-rays, producing the first in vitro radiation cell survival curve [21]. This assay has since been used for a wide variety of studies with many cell types using improved culture conditions, and for the testing of many potential chemotherapeutic agents. Till and McCulloch Following the work of Puck and Marcus, Till and McCulloch generated the first in vivo survival curves [22, 23]. They showed that when mouse bone marrow cells were injected into recipient mice that had been given total body irradiation to suppress endogenous haematopoiesis, visible colonies developed in the spleens that derived from cells in the graft. This work demonstrated that the cells injected into the mice were capable of self-renewal and it was speculated that these cells were stem cells. The evidence for this conclusion was that the curve from the number of marrow cells transplanted proportional to the number of colonies developed within the spleen. In addition, the radiation survival curve of cells that form colonies closely resembled survival curves developed by Puck and Marcus for in vitro cells [21]. This, however, was only indirect evidence and did not prove that the colonies originated from single cells, so the group carried out further experiments to determine the singl e cell origin on the colonies within the spleens [24]. Heavily irradiated bone marrow was transplanted into heavily irradiated recipient mice. The idea was that some cells containing genetic abnormalities caused by irradiation in the donor bone marrow cells would retain the ability to proliferate and produce clones containing this abnormality [24]. This worked to some extent, with a small number of colonies containing cells which all showed the same chromosome abnormality within that colony. It was hypothesised that if the capacity to form colonies is to be considered as a criterion to identify stem cells, then cells must lose this capacity upon undergoing differentiation. This hypothesis was tested by applying hypoxia as a differentiating pressure to mouse bone marrow, which resulted in a reduction in colony formation in the spleens of hypoxic mice [17]. They described how the number of colonies form in the spleens of mice in hypoxic conditions is reduced. This was thought to be du e to hypoxia stimulating erythropoiesis which stimulates erythropoietin, indicating that erythropoietin reducing colony forming production in the spleen. This data suggested that an increased demand for differentiated cells reduces the number of stem cells, resulting in the reduction of colony forming ability. Later Developments Since its development, the in vitro clonogenic assay has become a valuable tool in the study of cell growth and differentiation. [25]. Several adaptations to the original method have been made including immobilising cells in a top layer of 0.3% agar to avoid formation of tumor cell aggregates by random movement which might be confused with colony growth [26]. Agar has also been replaced by some groups with agarose, which is easier to handle (Laboise 1981) or methylcellulose which allows better recovery of the colony for replating. Others have simplified the culture medium and omitted the need for feeder cells. The exact protocol depends largely on cell type, but the basic system remains the same. The development of a protocol for secondary plating efficiency has proved a useful tool for the measurement of self-renewal and has the advantage of being able to identify cells that are able to undergo a large number of cell divisions [26]. This involves selecting specific colonies to deter mine their proliferative potential over a number of passages. Clonogenicity and Cell Renewal Hierarchy Clonogenic assays have been used to identify and morphologically characterise the three cell types above. Barrandon and Greens [27] work identified the clonal types of keratinocytes and linked this to their capacity for multiplication. They defined colonies as Holoclone, Meroclone or Paraclone. The Holoclone was described as a colony with a larger smooth nearly circular perimeter containing many small cells, which it has been suggested that these cells represent the proliferating self renewing stem cells. Paraclones were described as differentiated end cells which are more elongated and flattened in appearance, however paraclones can divide quite rapidly therefore classification of clonal type cannot be deduced form the study of growth rates alone or morphology alone. Meroclones were described as a combination of holoclones and paraclones. Relating morphology and colony size to clonogenicity can be used to further identify potential stem cells within the clonogenic assay and give mor e detail to the fate of their descendents. The differences in growth unit size may reflect several properties including different proliferative capacities and clonogenic cell kinetics. However, clonogenicity in vitro alone, does not define a stem cell, and other subpopulations, such as transit amplifying cells may also be able to produce a colony size of 32 or more cells. Although ability of a cell to form a colony implies substantial proliferative capacity, this does not unambiguously identify a stem cell [28]. Tumor Cell Heterogeneity and Hierarchy Certain characteristics have emerged from clonogenic studies on cells derived from human tumors. It was noticed that a few cells in each tumor were able to give rise to colonies in culture, whilst some colonies contained transit amplyifing cells undergoing a limited number of terminal divisions. Other cells (usually the majority) were non-proliferating stem cells. Looking at CFE and colony size of human tumors and replating experiments has demonstrated the heterogeneity of a wide range of tumor types including neoplastic human urothelium [29], melanoma [30, 31] and squamous carcinoma [32]. This supports the idea that cells within solid tumors consist of cellular hierarchies, which will be discussed further. The cancer stem cell model accounts for heterogeneity within a primary cancer by proposing that each cancer consists of a small population of cancer stem cells and a much larger population of cells which have lost their self-renewal capacity [5]. The clonogenic assay has been used explore this cellular heterogeneity present in human tumors, lending support to the stem cell model of tumor growth. Multiple myeloma has served as a valuable model in early clonogenic assay development. This was studied by Hamburger and Salmon in 1977 [33], who created an essentially selective system which restrict proliferation to cells capable of anchorage independent growth, thought to be a characteristic of stem cells [34]. They described an in vitro bioassay for human myeloma colony-forming units in culture which was applied to the study of patients with multiple myeloma and related monoclonal bone marrow derived B cell neoplasm. Bone marrow samples from patients with multiple myeloma and normal volun teers were cultured in the presence of an agar feeder layer prepared by either human type O+ washed erythrocytes or adherent spleen cells of BALB/c mice. They found a linear relationship between colony formation and the number of nucleated bone marrow cells plated. Multiple myeloma patients exhibited much higher numbers of colonies formed compared to normal volunteers. It was shown that the number of colonies was proportional to the number of colonies plated, suggesting that colonies were derived from single myeloma stem cells. This was the development of the human tumor stem cells assay. The Human Tumor Stem Cell Assay clonogenicity and cancer stem cells The ability to grow human solid tumors in two-layer soft agar culture was developed for the clinical application of testing in vitro tumor sensitivity or resistance to chemotherapeutic agents. It is a possible means by which anticancer drugs can be selected for activity against tumor cells from a patient [35] as a way of tailoring chemotherapeutic regimes to individual patients and of testing new cytostatic agents [36]. The assay assesses treatment effects of stem cells by a testing their ability to reproduce and form a colonies of cells. Using semi-solid agar with enriched medium supports colony growth from cell suspensions from a variety of human tumors. A semi-solid medium suppresses the growth of most normal cells and there is evidence of the malignant nature of these colonies [33] . An important consideration is the relationship between the response of clonogenic cells to drugs in vitro and the response of the tumor to the same drug in the patient [10]. The stem cell model of human cancer suggests that cure or duration of remission after clinical treatment should correlate only with killing of stem cells. Assessment of treatment effects on an unselected cell population (eg on the basis or morphological criteria) is therefore likely to be misleading since the effects on a small population of stem cells will be masked by those on the large population of stem cells. Human tumors of a single histological type appear to have a pattern of response in vitro that is similar to their clinical behaviour. Within a histological type, tumours are heterogeneous in response both in vitro and in vivo. Studies directly comparing the response in vitro with the subsequent clinical response have shown important correlations. The proportion of human tumors that grow with a plating efficiency sufficient for assessment of drug activity (à ¢Ã¢â‚¬ °Ã‚ ¥30 colonies per 500,000 cells plated is frequently less that 50%. Usually only a proportion of these tumors will manifest in vitro sensitivity [37]. There have been a wide range of predictive value positives reported for the human clonogenic tumour cell assay when applied to a patient population with an expected clinical response rate of 15-49% [38]. This value could be misleading and in practice may only be workable for cytotoxicity testing for only one third of specimens tested. The limitation exits that not all sam ples will produce clones in vitro so those that do may exhibit a treatment bias [35]. Other problems with the use and interpretation of human tumor clonogenic assays include low plating efficiency and small proportion of tumors available for testing; difficulty in preparing single cell suspensions, production of only small quantities of data, and problems defining drug sensitivity and response criteria [35]. Factors influencing size of sub-populations It has been proposed that as in normal cell populations, human tumor cell populations are also heterogeneous and comprise stem cells, non-stem transitional cells with limited proliferative capacity and end cells [6]. MacKillop suggested that four factors may influence the relative size of these subpopulations: The probability of self-renewal (Psr) of stem cells (producing two daughter stem cells). The distribution of cells within the system can be treated mathematically by assuming probability functions. The potential of the transitional cells for further cell division, as defined by clonal expansion number (n=number of generations between the first generation non-stem cells and the end cells.) The relative effect of cell loss on each subpopulation (Stem cells, transit amplifying, end cells) as described by cell loss factors (ÃŽÂ ¦s, ÃŽÂ ¦t ÃŽÂ ¦ ec). The number of generations of cell proliferation following initiation of the tumor cell population for individual stem cell. Stem cell division in normal tissue must provide a supply of differentiated functional cells to compensate for physiological losses and at the same time maintain a constant stem cell population. A probability of self-renewal in which two stem cells daughters Psr =0.5, would yield a steady state [28]. If no cell loss occurs, it has been modelled that the number of stem cells will increase exponentially with Psr > 0.5 [6]. For the simplest case in which all non-stem cells are end cells (n=0) the proportion of stem cells increases linearly with increasing Psr. and the proportion of stem cells in a tumor decreases as the extent of multiplication of the transitional cell compartment. This results in the stem cell being the less common cell type numerically than transit amplifying and differentiated end cells. These scenarios are affected by cell loss which may occur through necrosis, migration or differentiation, of which only differentiation is selective of cell type. A selective loss th rough differentiation increases the population of stem cells. The modelling of tumor cell growth has implications for the use of clonogenic assays as predictors of the stem cell fraction on human tumors, especially in regards to cut-off points in terms of colony size and determining which cells represent the stem cell fraction [6]. Between studies there are differences between how colonies are scored morphologically and numerically and how long cells are allowed to grow [31] and considering this evidence may be an important issue when comparing data between different studies. Clonogenicity in cell lines and stem cells in cell lines Clonogenicity has recently been used to identify stem cell properties of cells in long term culture cancer cell lines. The colony forming efficiency and secondary plating efficiency of carcinoma derived cell lines including head and neck squamous, breast [39] and prostate [39-42] were investigated and considered to contain potential stem cells. These studies show that cell lines show clear differences between clonal types (holoclone, meroclone, paraclone) and have similar properties in this respect to normal epithelial cells [39]. The proportions of clonal types between the carcinoma cell lines vary greatly. DU145 colonies were evenly spread in number between the clonal types, whereas PC3 cells produced mainly meroclones and LNCaP cells produced mainly paraclones [41], all based on colony morphology. These studies have also looked at the relationship between potential cancer stem cell markers and clonogenicity. CD133 enriched DU145 cells were assayed for clonogenicity, but no difference was found between the positive and negative cells [41], but when isolated CD44+ integrin ÃŽÂ ±2ÃŽÂ ²1+ CD133+ sorted cells were compared against CD44+ integrin ÃŽÂ ±2ÃŽÂ ²1low CD133low a higher CFE was observed in conjunction with a marked difference in morphology to CD44+ integrin ÃŽÂ ±2ÃŽÂ ²1-/low CD133- in DU145 MACS sorted cells [40]. Immunocytochemistry demonstrated that different clonal types showed varying levels of expression of CD44, ÃŽÂ ±2ÃŽÂ ²1 integrin and ÃŽÂ ²-catenin in PC-3 [42] and DU145 clones [39]. There is further evidence to suggest the presence of cells with stem cell behaviour such as dye-exclusion and higher clonogenicity, in several human epithelial cell lines [39, 43-45], which further supports the idea that cell lines contain stem cells. The ad vantage of cancer cell lines that contain cells displaying stem cell characteristics would facilitate the study of molecular pathways and the properties that define the cancer stem cells in vitro. Recent Developments Much progress has been made in the modelling of the leukemic diseases, where the level of heterogeneity was first and most thoroughly explored. Human cells fulfilling the properties expected of drug resistant cancer stem cells were initially isolated from blood cancers [2]. Improvements in the genetics of recipient mice have led to the definition SCID-repopulating cell (SRC). Many improvements to the NOD/SCID murine model continue to be made by using recipient mice that are engineered to be deficient in natural killer (NK) and macrophage activity; part of that innate immune system. It has been demonstrated that a small subpopulation of acute myeloid leukaemia cells with an immature immunophenotype possess the ability colonise immune deficient NOD/SCID mice to give rise to more differentiated leukaemia cells and to recapitulate the heterogeneous phenotype of the bulk tumour [46]. The phenotypically more mature cells failed to engraft in mice, suggesting the presence of an identifiable tumour cell hierarchy. These cells are referred to as tumour initiating cells. Cancer Stem Cell Identification CSCs have been defined on the basis of their ability to seed tumours in animal hosts, to self renew and to spawn differentiated progeny (non-CSCs)[47]. Pioneering work in this area originated from studies on leukaemia stem cells and later included demonstrations of CSCs in solid tumours, particularly breast and brain cancers. However, work in solid tumours has proved challenging. The frequency of CSCs in solid tumours is highly variable [48]. Difficulties with tumour CSC identification Evidence for the existence of cancer stem cells in solid tumours has been more difficult than in the haematopoietic system to obtain for several reasons: 1) The cells within the tumour are less accessible. Tissue has to undergo mechanical or enzymatic digestion to obtain a single cell suspension which can be analysed. 2) There is a lack of functional assays suitable for detecting and quantifying normal stem cells from many organs. 3) Only a few cell surface markers have been identified and characterised. Of these there is no one marker which is specific for a stem cell or cancer stem cells and for selection they often have to be used in combination. Cancer Stem Cell Markers Stem cells are most commonly identified by staining for cell surface markers, exclusion of fluorescent dyes or labelling with tritiated thymidine [3] . The technology to develop monoclonal antibodies to specific molecules and flow-cytometery based sorting and analysis has been a big driving force in recent CSC developments. Much work has been done to define cell surface markers. It has been shown that two distinct subpopulations can be separated from a single tumour that differ in their cell surface markers and their ability to seed new tumours in vivo. Most of the currently used markers do not recognise functional stem cell activity. By using combinations of cell surface markers, the homogenous purification of stem cells can be obtained [3]. Table 1 below reviews the current suggested markers for some tumour types. The use of animal models has allowed identification and assessment of markers that are expressed by cancer stem cells. The most convincing demonstration of identity CSC s elected by biomarkers comes from serial transplantation of cellular populations into animal models. The CSC containing fraction should re-establish the phenotypic characteristics of the original tumour [48]. In 1997 Bonnet et al showed that the ability to transfer human leukaemias into NOD/SCID mice was retained by a small proportion of cells with the CD34+, CD38- phenotype [46]. The CD44 and CD133 markers have emerged as potential markers of immature epithelial cells for isolating CSCs in several tissue types including brain and prostate. Cells have been isolated from several tumour types and serially transplanted in xenograft models: Breast CD44+ CD24-/low established tumours in recipient mice. Brain CD133+ enriched cells. Prostate Side population CD44+ enriched. In these experiments small numbers of selected cells produced tumours in recipient mice. In this instance CSCs can on

A Clean, Well-Lighted Place and The Jilting Of Granny Weatherall :: The Jilting Of Granny Weatherall

Katherine Porter's The Jilting Of Granny Weatherall and A Clean, Well-Lighted Place written by Ernest Hemmingway What are the thoughts that go through the minds of those who near death? These are the questions at the heart of A Clean, Well-Lighted Place written by Ernest Hemmingway and Katherine Porter's The Jilting Of Granny Weatherall. The main focus of A Clean, Well-Lighted Place is on the pain of old age suffered by a man that we meet in a cafe late one night. Hemingway contrasts light and dark to show the difference between this man and the young people around him, and uses his deafness as an image of his separation from the rest of the world. Similarly, in The Jilting Of Granny Weatherall, Porter discusses the regrets of an old woman revealed by her reactions to her being left at the altar and her slow death sixty years later. Near the end of both stories, the authors show us the desperate emptiness of a life near finished without the fruit of its labor, and the aggravation of the old restless mind that cannot find peace. Throughout the stories stark images of desperation show the lives of the two main characters at a point when they have realized the futility of life. In the story, The Jilting of Granny Weatherall, written by Katherine Porter, Granny Weatherall is a character of depth. Her name is synomonous with her character. Three main qualities of her character are her strength, her endurance, and her vulnerability. Her strength is not so much physical but mental. She lies upon her bed contemplating all that she needs to do. Her daughter Cornelia does not even come close to handling affairs as well as she does in her own mind. In addition, she tell the Doctor Leave a well women alone...I'll call you when I need you. She does not like the patronizing position that she finds herself in. The fact that she has already avoided death once seems to add to her image of strength. As we follow her mental ramblings we obtain insight to her character as a woman that has endured heartache as well as hardship. A Clean, Well-Lighted Place and The Jilting Of Granny Weatherall :: The Jilting Of Granny Weatherall Katherine Porter's The Jilting Of Granny Weatherall and A Clean, Well-Lighted Place written by Ernest Hemmingway What are the thoughts that go through the minds of those who near death? These are the questions at the heart of A Clean, Well-Lighted Place written by Ernest Hemmingway and Katherine Porter's The Jilting Of Granny Weatherall. The main focus of A Clean, Well-Lighted Place is on the pain of old age suffered by a man that we meet in a cafe late one night. Hemingway contrasts light and dark to show the difference between this man and the young people around him, and uses his deafness as an image of his separation from the rest of the world. Similarly, in The Jilting Of Granny Weatherall, Porter discusses the regrets of an old woman revealed by her reactions to her being left at the altar and her slow death sixty years later. Near the end of both stories, the authors show us the desperate emptiness of a life near finished without the fruit of its labor, and the aggravation of the old restless mind that cannot find peace. Throughout the stories stark images of desperation show the lives of the two main characters at a point when they have realized the futility of life. In the story, The Jilting of Granny Weatherall, written by Katherine Porter, Granny Weatherall is a character of depth. Her name is synomonous with her character. Three main qualities of her character are her strength, her endurance, and her vulnerability. Her strength is not so much physical but mental. She lies upon her bed contemplating all that she needs to do. Her daughter Cornelia does not even come close to handling affairs as well as she does in her own mind. In addition, she tell the Doctor Leave a well women alone...I'll call you when I need you. She does not like the patronizing position that she finds herself in. The fact that she has already avoided death once seems to add to her image of strength. As we follow her mental ramblings we obtain insight to her character as a woman that has endured heartache as well as hardship.

How Osmosis Affects A Potato Chip Essay -- GCSE Biology Osmosis Course

How Osmosis Affects A Potato Aim: - To See How Osmosis Affects A Potato Preliminary work Prediction: -I predict that the weight of the potato in the sugar solution will decrease and the weight of water will increase. I predict that the weight of the potato in the sugar solution will decrease when it reaches 3:1 (salt: water). In put Variables: -Molarity -Size of potato -Mass of Water -Molarity of Sugar -Length of time in the solution -Temperature of water Out put variables: -Weight of potato Key variables: -Molarity of sugar. This is a key variable because it has the most effective outcome because osmosis only works when there are different molarities in and outside of the potato other wise the diffusion theory of osmosis wont work. We are going to keep a fair test by: - Keeping all the volume of water the same in each test tube - Keeping the starting weight of the potato the same to begin with - When removing the excess water of the potato make sure all excess water is removed but without squeezing any water out of the potato - Keeping the temperature of the water the same - Use the same type of potato (grown from the same potato) We will keep the experiment safe by making sure that all the test tube racks are in a suitable position so they wont easterly be knocked over. Preliminary results --------------------------------------------- Sugar Water Time left in 0.44g 0.44 Start 0.43g 0.44 5mins 0.42g 0.45 10mins 0.49g 0.46 15mins 0.38g 0.46 20mins --------------------------------------------- The table above shows the weight of the potato. Prediction I predict that the weight of the potato in the sugar solution will go down and the weight of the water will decrease because the water molecules in the sugar solution are small enough to diffuse through a semi-permeable membrane in the potato is the high concentration of water and water will only go through from a high concentration to a low concentration of water. Water goes into a potato sample because there is a higher concentration of water out side the potato than inside of the potato and water will go from a high concentration to a low concentration therefore the water will go into the potato and... ... to be sure to show a constant pattern. We didn't have any anomalous results maybe because we mad sure that we left each potato in the solution an equal amount of time. Also when we removed access water we were very careful not to squeeze any water out of the potato other wise it would of made it an unfair test. To improve reliability and accuracy next time in the prim nary plan I would make sure that my prediction was detailed so I would understand everything much clearer in order to get a better set of results. Also the preliminary experiment next time will be a lot more accurate in the way that we should take more care in time that the potato is left in the solution for how ever long of a time it should be left in. The main plan could be longer and in more detail so that it is more clear to read and understand. The amount of results that we got was just about enough to work out and see weather the prediction was correct. This means that next time we should do more sets of results to get a more accurate outcome. To help back up this experiment we could use more chats of graphs showing rate of osmosis in time and other ways of showing how osmosis affects a potato.

The Concept of Perfectionism Essay examples -- Perfectionism Perfectio

The Concept of Perfectionism Do you push yourself to be the best? Do you get mad at yourself for not doing the best? Do you delay assignments till the last possible limit because of fear of rejection? Do you feel horrible when work isn’t done to your best ability of when minor failures seem like catastrophic ones? These are all signs of what is known as perfectionism (Pacht 1984). If you seem to agree with most of these things then you might be a perfectionist. According to Webster’s dictionary, it states that perfectionism is "a disposition which regards anything less than perfect, unacceptable." Many people in the world suffer from perfectionism. So is that case of Mike Bellah. His perfectionism lead him to a lifestyle where he lost who he was. He states, "When we’re always playing a part, we no longer know who we really are." Perfectionists try to do everything perfect leading them to an unstable, unsatisfying life. There are many characteristics and effects of perfectionism. Coping with the disorder of being a perfectionist can lead to a much more stable life. There are many characteristics and causes of perfectionism "It’s a compulsive guide to unrealistic goals" says psychiatrist David Burns. "Setting high personal standards and goals, and working hard to attain them is appropriate," he states, "however, perfectionists set excessively high goals and strive compulsively to achieve them." Perfectionists have the constant drive to be perfect. Anything less than the best is unacceptable to them. They refuse to live with anything than the best. The constant strive for excellence in everything that one does is one key characteristic when describing 2 perfectionism. Their measurement of their worth is entirely in terms of productivity and accomplishment. Perfectionists try to do so much to please others, and to show how much they can do, and overlook what they really want to do in life. They might take on so many jobs and get in over their head. They can’t say no to an idea because they would consider that failure. Many times, perfectionists start things over because things aren’t going perfect (Pacht 1984). Some have long delays in completing assignments, or repeatedly starting over on assignments because the work must be prefect from the beginning and continue to be perfect as one goes along. The causes of perfectionism can be described by th... ...nt without always accomplishing everything perfect, their life will become better manageable. Coping with perfectionism may not be easy, but these are a few key ideas to help those live better in life, and instead of trying to be perfect, to be "above average" or "normal." The many individuals in the world who suffer with perfectionism deal with it day to day. Perfectionists want to be perfect, which leads to a life that is not perfect. You can still set high goals for yourself, but they should be ones that can be accomplished. Some people try and harness perfectionism to work for them than letting it control their lives. They aren’t ashamed of it, and understand that it serves a useful purpose. Some people are able to control it, and some people aren’t. The concept of being perfect is one that cannot be achieved, because no one is ever perfect. It is a symbol of what is correct 100% and because we are human beings and not machines it is not possible. Everyone has goals for themselves, but to live a healthy life, we need to make them realistic. We can still give our best, but we need to please ourselves and be aware of who we are before we need to be perfect for others.

Culture and Moral Values: Are they changing? Essay

As we enter into a new world of technology our culture and moral values are simultaneously fading away with every new invention. We seem to be forgetting the important things in life. Reading the works of William Wordsworth and other poetic authors, some people may start to see how men and women cherished life and nature at one point in time. Today, we look at nature as if it is meant to be slaves for our needs in order to provide us with food, water, and air. Nature provides for us and we treat this beautiful gift as a slave that works to satisfy our needs, not taking care of our gift, forgetting to cherish every thing that nature has given to the human race. People forget that nature was given to us as a masterpiece of strength and power through God. Man’s ability to strive for more in life seems to destroy his vision of what he must base his values of life on as a Christian human being. The subject of â€Å"industrial organization† applies the economist’s mode ls of price theory to the industries in the world around us (Caves 15). Industrialization is a great discovery that helped revolutionize the life of people at a very rapid pace. It seems that ever since man became intelligent enough to create easy ways of life, his cultural values of family, work, and life have become a task for machines. Instead of overtaking our ideas and inventions, controlling them, and molding them into our own way of life, we allow industrialization of new technology to pave the way of life we live. In this essay we will be discussing the process of industrialization, explaining the effects it has had on culture and moral values in the time of our ancestors, as apart from the culture and moral values of today’s society. In the new world today industrialization is a big part of technology. It seems that the more the industry field starts to grow, the more we seem to forget the real values of life. We have now entered a new phase, in which adults all over the world have to recognize that all children’s experience is different from their own (Mead 23). Television, computers, cars, and other manmade inventions are beginning t o bring our normal hard working way of life to extinction. Instead of trying to keep the ideal of working hard for something that a person may want in life, we depend on new technology to create an easier life for our own selfish purposes. Today many people take nature and life for granted. Industrialization, having one of the biggest portions of why this problem  exists, will start to control the relationship of man and the outdoors. Industrialization is the main work force of our life. It is about to destroy every thing that God gave to us as a spiritual gift. God did provide us with the knowledge to create the industry work field. But he did not intend for us to misuse our power of intelligence. God gave us the gift of bringing new life into the world as human beings. This is something that we should cherish and respect as children of Jesus the Messiah. Today scientists are trying to produce life through cloning. We should be ashamed to even try to create life or clone life; it is meant for a living thing to be born then die. Industrialization is not wrong as of today, but sooner are later we will take it too far and end up regretting even trying to abuse our power. Growing up as a young man in an African American family, stories were told in order to explain the c oncept of hard work and the willingness to work hard in order to get what one needed, not wanted. We, as young adults, should be thankful for the new network of industry and never take any part of this wonderful life for granted. In the days of our ancestors they cherished every little thing that they had to work for in life. Moral values meant something special in those times, and every one loved to enjoy the beautiful outdoors. Industrialization back then meant a shovel, horse, and manpower in order to eat on an everyday basis. Children played with ropes tied to a cane, read books, and studied the outdoors. They never once had the evil, selfish moral values that we have today. Selfishness may have exited back in those days, but no one really had too much to be selfish about in those times. Culture had a totally different meaning for our ancestors; they understood the meaning of true moral values. â€Å"Every human society has its own shape, its own purposes, and its own meanings. Every human society expresses these, in institutions, and in arts and learning (Ferguson 69).† Art, music, life, and religion were a big part of everyday life. Many great poets and authors came from this ancestral period. Music was not just something to listen to but also something to study and appreciate. If only we could recapture those everlasting moments that our ancestors enjoyed through out their lives we would never overstep our boundaries towards a more technological world. In today’s society Industrialization has become a major part of everyday life. Computers, transportation, entertainment, and technology have become like a disease  that is spreading throughout our young youth, destroying all the moral values that had been set in the time of our ancestors (Ferguson 45). How can we raise our kids not to be selfish and arrogant in the world today when there is a specific way of life? There is a certain way to dress, talk, walk, eat, and even sleep. People fail to realize that at one point in the past there was a time when people were not able to choose when to sleep or how to dress. Industrialization has just about created a new way of life where humans just lie around the house and get fat all day. It is real funny how we are the most intelligent race on the face of the earth, but we can’t seem to control our own despicable ways. Everyone at some point in his or her life wishes there was an easier way to perform a task or a short cut th rough a difficult task. Children that are following the path that we are creating for them will lose the little feeling that a person gets from gaining something from nothing. If we just hand things to children every time they ask for them how can we capture the moral values from our ancestors. In order for us to reveal true culture of nature, we must travel far from technology and Industrialization. We must learn to cherish every thing that has been accomplished for use as Americans and children of God. Culture and moral values to some may be very important issues but to others may just be nonexistent being that fade away slowly every second. If we conceive ourselves in technology we will lose our true heritage, forgetting what God has intended for us through our knowledge. Our intelligent minds are meant for us to have a better view of our culture and moral values. This basically means that our ability to strengthen our way of living through technology should have no effect on changing the way our values and culture progress to with everyday life. We should not take every thing that has been blessed upon us for granted. When will we ever go back to the old way of life and try to counteract it with today’s Technology? Think about how wonderful a world we would have if everyone worked to the maximum potential. If we really tried as hard as our ancestors did we may have a cure for all diseases, we may stop world hunger, or even succeed in world peace. Until we realize that our life is based on more than just materialistic items, the new world of industrialization will take over our minds and destroy our bodies. Works Cited Page Caves, Richard. American Industry: Structure, Conduct, Performance. Prentice Hall, Inc. New Jersey: 1987. Ferguson, John. Moral Values in the Ancient World. Methuen & Co, London: 1921. Mead, Margaret. Culture and Commitment. Columbia University Press. New York: 1978.